Lieutenant Governors who became Governor are hyperlinked below to their entries in the Governor's Portrait Collection at the Indiana Historical Bureau, where brief biographies are also located.
Any gaps in time not accounted for below are periods when the office was vacant due to death, resignation, or the occasional need for the Lieutenant Governor to assume the responsibilities of the Governor.
| 1 | Christopher Harrison | Dem. Rep. | 11/7/1816-12/17/1818 |
| 2 | Ratliff Boon | Jeff. Rep. | 12/8/1819-9/12/1822 |
| 3 | Ratliff Boon | Jeff. Rep. | 12/4/1822-1/30/1824 |
| 4 | John H. Thompson | Jacksonian | 12/7/1825-12/3/1828 |
| 5 | Milton Stapp | Indep. | 12/3/1828-12/7/1831 |
| 6 | David Wallace | Whig | 12/7/1831-12/6/1837 |
| 7 | David Hillis | Whig | 12/6/1837-12/9/1840 |
| 8 | Samuel Hall | Whig | 12/9/1840-12/6/1843 |
| 9 | Jesse D. Bright | Dem. | 12/6/1843-12/6/1845 |
| 10 | Paris C. Dunning | Dem. | 12/9/1846-12/26/1848 |
| 11 | James H. Lane | Dem. | 12/5/1849-1/10/1853 |
| 12 | Ashbel P. Willard | Dem. | 1/10/1853-1/12/1857 |
| 13 | Abram A. Hammond | Dem. | 1/12/1857-10/3/1860 |
| 14 | Oliver P. Morton | Rep. | 1/14/1861-1/16/1861 |
| 15 | Conrad Baker | Rep. | 1/9/1865-1/23/1867 |
| 16 | Will Cumback | Rep. | 1/11/1869-1/13/1873 |
| 17 | Leonidas Sexton | Rep. | 1/13/1873-1/13/1877 |
| 18 | Isaac P. Gray | Dem. | 1/13/1877-11/2/1880 |
| 19 | Thomas Hanna | Rep. | 1/10/1881-1/12/1885 |
| 20 | Mahlon D. Manson | Dem. | 1/12/1885-8/3/1886 |
| 21 | Robert S. Robertson | Rep. | 1/10/1887-1/13/1889 |
| 22 | Ira J. Chase | Rep. | 1/14/1889-11/24/1891 |
| 23 | Mortimer Nye | Dem. | 1/9/1893-1/11/1897 |
| 24 | William S. Haggard | Rep. | 1/11/1897-1/14/1901 |
| 25 | Newton W. Gilbert | Rep. | 1/14/1901-1/9/1905 |
| 26 | Hugh Thomas Miller | Rep. | 1/9/1905-1/11/1909 |
| 27 | Frank J. Hall | Dem. | 1/11/1909-1/13/1913 |
| 28 | William P. O'Neill | Dem. | 1/13/1913-1/8/1917 |
| 29 | Edgar D. Bush | Rep. | 1/8/1917-1/10/1921 |
| 30 | Emmett F. Branch | Rep. | 1/10/1921-4/30/1924 |
| 31 | F. Harold Van Orman | Rep. | 1/12/1925-1/14/1929 |
| 32 | Edgar D. Bush | Rep. | 1/14/1929-1/9/1933 |
| 33 | M. Clifford Townsend | Dem. | 1/9/1933-1/11/1937 |
| 34 | Henry F. Schricker | Dem. | 1/11/1937-1/13/1941 |
| 35 | Charles M. Dawson | Rep. | 1/13/1941-1/8/1945 |
| 36 | Richard T. James | Rep. | 1/8/1945-4/1/1948 |
| 37 | Rue J. Alexander | Rep. | 4/14/1948-1/2/1949 |
| 38 | John A. Watkins | Dem. | 1/10/1949-1/12/1953 |
| 39 | Harold W. Handley | Rep. | 1/12/1953-1/14/1957 |
| 40 | Crawford F. Parker | Rep. | 1/14/1957-1/9/1961 |
| 41 | Richard O. Ristine | Rep. | 1/9/1961-1/11/1965 |
| 42 | Robert L. Rock | Dem. | 1/11/1965-1/13/1969 |
| 43 | Richard E. Folz | Rep. | 1/13/1969-1/8/1973 |
| 44 | Robert D. Orr | Rep. | 1/8/1973-1/12/1981 |
| 45 | John M. Mutz | Rep. | 1/12/1981-1/9/1989 |
| 46 | Frank L. O'Bannon | Dem. | 1/9/1989-1/13/1997 |
| 47 | Joseph E. Kernan | Dem. | 1/13/1997-9/13/03 |
| 48 | Katherine L. Davis | Dem. | 10/20/03-1/10/05 |
| 49 | Becky Skillman | Rep. | 1/10/2005-1/14/2013 |
| 50 | Sue Ellspermann | Rep. | 1/14/2013-3/2/2015 |
| 51 | Eric Holcomb | Rep. | 3/3/2015-1/9/2017 |
| 52 | Suzanne Crouch | Rep. | 1/9/2017-present |